An Interactive Jmol Tutorial about PTEN PROTEIN

- The PTEN protein gene, was initially identified as a tumor suppressor lost from 10q23 region of the chromosome. The PTEN gene was located in a chromosome region, which had high susceptibility to mutation and is usually altered in most cancer patients.

- Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase enzyme. The enzyme, has roles that are related to the phosphatase enzyme and also independent roles that are not related to phosphatase activity.

-The stability, localization, phosphatase activity and conformation of the enzyme, are regulated by post-translational modifications such as oxidation, acetylation, phosphorylation, SUMOylation and ubiquitination, and it can is also done through protein–protein interactions.

- The tumor suppression effect by PTEN proteins, that is influenced by its regulation process.

Figure 1: Shows the 3 D structure of PTEN protein, where the blue represents the PBD region, red represents the HCXXGXXRS/T region and orange represents C2 and PDZ binding region (Worby & Dixon, 2014).

Figure 2: Illustrates the regions of posttranscriptional modifications in PTEN protein (Worby & Dixon, 2014).